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Институт физиологически активных веществ
Федерального государственного бюджетного учреждения науки
Федерального исследовательского центра проблем химической физики и медицинской химии
Российской академии наук
Избранные публикации:
2023
- Bachurin, S. O.; Aksinenko, A. Y.; Makhaeva, G. F.; Shevtsova, E. F. Multipharmacophore strategy in medicinal chemistry for the design of drugs for the treatment of Alzheimer’s and some other neurodegenerative diseases. Russ Chem Bull 2023, 72, 130-147. DOI:10.1007/s11172-023-3718-01
- Makhaeva, G. F.; Bachurin, S. O. Multifunctional Inhibitors of Cholinesterases for the Therapy of Alzheimer’s Disease (A Review). Russ J Gen Chem 2023, 93, Suppl. 2, S1–S22. DOI:10.1134/S1070363223150161
- Richardson, R. J.; Makhaeva, G. F. Organophosphorus compounds. In Reference Module in Biomedical Sciences, Elsevier: 2023; pp 1-11. DOI:10.1016/b978-0-12-824315-2.00455-3
- Nurieva, E. V.; Alekseev, A. A.; Zefirov, N. A.; Milaeva, E. R.; Kovaleva, N. V.; Proshin, A. N.; Makhaeva, G. F.; Zefirova, O. N. Annulated bicyclic isothioureas: identification of active and selective butyrylcholinesterase inhibitors. Mendeleev Commun 2023, 33, 77-79. DOI:10.1016/j.mencom.2023.01.024
- Makhaeva, G. F.; Kovaleva, N. V.; Rudakova, E. V.; Boltneva, N. P.; Lushchekina, S. V.; Astakhova, T. Y.; Timokhina, E. N.; Serebryakova, O. G.; Shchepochkin, A. V.; Averkov, M. A.; Utepova, I. A.; Demina, N. S.; Radchenko, E. V.; Palyulin, V. A.; Fisenko, V. P.; Bachurin, S. O.; Chupakhin, O. N.; Charushin, V. N.; Richardson, R. J. Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit beta-amyloid self-aggregation: potential therapeutic agents for Alzheimer’s disease. Front Pharmacol 2023, 14, 1219980. DOI:10.3389/fphar.2023.1219980
- Khudina, O. G.; Grishchenko, M. V.; Makhaeva, G. F.; Kovaleva, N. V.; Boltneva, N. P.; Rudakova, E. V.; Lushchekina, S. V.; Shchegolkov, E. V.; Borisevich, S. S.; Burgart, Y. V.; Saloutin, V. I.; Charushin, V. N. Conjugates of Amiridine and Thiouracil Derivatives as Effective Inhibitors of Butyrylcholinesterase with Potential to Block beta Amyloid Aggregation. Arch Pharm 2023, e2300447. DOI:10.1002/ardp.202300447
- Lapshina, M. A.; Shevtsova, E. F.; Grigoriev, V. V.; Aksinenko, A. Y.; Ustyugov, A. A.; Steinberg, D. A.; Maleev, G. V.; Dubrovskaya, E. S.; Goreva, T. V.; Epishina, T. A.; Zamoyski, V. L.; Makhaeva, G. F.; Fisenko, V. P.; Veselov, I. M.; Vinogradova, D. V.; Bachurin, S. O. New Adamantane-Containing Edaravone Conjugates as Potential Neuroprotective Agents for ALS Treatments. Molecules 2023, 28, 7567. DOI:10.3390/molecules28227567
- Makhaeva G.F., Rudakova E.V., Kovaleva N.V., Boltneva N.P., Lushchekina S.V., Proshin A.N., Serkov I.V., Bachurin S.O. New highly efficient multifunctional cholinesterase inhibitors based on the conjugation of amiridine and tacrine homolog. Russian Chemical Bulletin 2023, 72, 2738-2748
- Makhaeva, G. F.; Kovaleva, N. V.; Rudakova, E. V.; Boltneva, N. P.; Grishchenko, M. V.; Lushchekina, S. V.; Astakhova, T. Y.; Serebryakova, O. G.; Timokhina, E. N.; Zhilina, E. F.; Shchegolkov, E. V.; Ulitko, M. V.; Radchenko, E. V.; Palyulin, V. A.; Burgart, Y. V.; Saloutin, V. I.; Bachurin, S. O.; Richardson, R. J. Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease. Int J Mol Sci 2023, 24, 2285. DOI:10.3390/ijms24032285
- Burgart, Y. V.; Elkina, N. A.; Shchegolkov, E. V.; Krasnykh, O. P.; Makhaeva, G. F.; Triandafilova, G. A.; Solodnikov, S. Y.; Boltneva, N. P.; Rudakova, E. V.; Kovaleva, N. V.; Serebryakova, O. G.; Ulitko, M. V.; Borisevich, S. S.; Gerasimova, N. A.; Evstigneeva, N. P.; Kozlov, S. A.; Korolkova, Y. V.; Minin, A. S.; Belousova, A. V.; Mozhaitsev, E. S.; Klabukov, A. M.; Saloutin, V. I. Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-Ones for Pharmaceuticals. Molecules 2023, 28, 59. DOI:10.3390/molecules28010059
2022
- Makhaeva, G. F.; Proshin, A. N.; Kovaleva, N. V.; Rudakova, E. V.; Boltneva, N. P.; Lushchekina, S. V.; Astakhova, T. Y.; Serkov, I. V.; Kalashnikova, I. P.; Bachurin, S. O. Synthesis and study of the biological activity of thiourea-containing amiridine derivatives as potential multi-target drugs for the treatment of Alzheimer’s disease. Russ Chem Bull 2022, 71, 2404-2415. DOI:10.1007/s11172-022-3668-y
- Bachurin, S. O.; Shevtsova, E. F.; Makhaeva, G. F.; Aksinenko, A. Y.; Grigoriev, V. V.; Goreva, T. V.; Epishina, T. A.; Kovaleva, N. V.; Boltneva, N. P.; Lushchekina, S. V.; Rudakova, E. V.; Vinogradova, D. V.; Shevtsov, P. N.; Pushkareva, E. A.; Dubova, L. G.; Serkova, T. P.; Veselov, I. M.; Fisenko, V. P.; Richardson, R. J. Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease. Int J Mol Sci 2022, 23. DOI:10.3390/ijms232213925
- Burgart, Y. V.; Makhaeva, G. F.; Krasnykh, O. P.; Borisevich, S. S.; Agafonova, N. A.; Kovaleva, N. V.; Boltneva, N. P.; Rudakova, E. V.; Shchegolkov, E. V.; Triandafilova, G. A.; Gazizov, D. A.; Serebryakova, O. G.; Ulitko, M. V.; Khursan, S. L.; Saloutin, V. I.; Richardson, R. J. Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity. Molecules 2022, 27, 7722. DOI:10.3390/molecules27227722
- Elkina, N. A.; Grishchenko, M. V.; Shchegolkov, E. V.; Makhaeva, G. F.; Kovaleva, N. V.; Rudakova, Е. V.; Boltneva, N. P.; Lushchekina, S. V.; Astakhova, T. Y.; Radchenko, E. V.; Palyulin, V. A.; Zhilina, E. F.; Perminova, A. N.; Lapshin, L. S.; Burgart, Y. V.; Saloutin, V. I.; Richardson, R. J. New Multifunctional Agents for Potential Alzheimer's Disease Treatment Based on Tacrine Conjugates With 2-Arylhydrazinylidene-1,3-Diketones. Biomolecules 2022, 12, 1551. DOI:10.3390/biom12111551
- Grishchenko, M. V.; Makhaeva, G. F.; Burgart, Y. V.; Rudakova, E. V.; Boltneva, N. P.; Kovaleva, N. V.; Serebryakova, O. G.; Lushchekina, S. V.; Astakhova, T. Y.; Zhilina, E. F.; Shchegolkov, E. V.; Richardson, R. J.; Saloutin, V. I. Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease. ChemMedChem 2022, 17, e202200080. DOI:10.1002/cmdc.202200080
- Grishchenko, M. V.; Elkina, N. A.; Makhaeva, G. F.; Burgart, Y. V.; Boltneva, N. P.; Rudakova, E. V.; Shchegolkov, E. V.; Kovaleva, N. V.; Serebryakova, O. G.; Saloutin, V. I. Conjugates of Tacrine with Aminomethylidene-Substituted Malonates: Synthesis and Biological Evaluation. Russ J Gen Chem 2022, 92, 2259-2266. DOI:10.1134/s1070363222110093
- Makhaeva, G. F.; Kovaleva, N. V.; Boltneva, N. P.; Rudakova, E. V.; Lushchekina, S. V.; Astakhova, T. Y.; Serkov, I. V.; Proshin, A. N.; Radchenko, E. V.; Palyulin, V. A.; Korabecny, J.; Soukup, O.; Bachurin, S. O.; Richardson, R. J. Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile. Molecules 2022, 27, 1060. DOI:10.3390/molecules27031060
- Shchegolkov, E. V.; Boltneva, N. P.; Burgart, Y. V.; Lushchekina, S. V.; Serebryakova, O. G.; Elkina, N. A.; Rudakova, E. V.; Perminova, A. N.; Makhaeva, G. F.; Saloutin, V. I. 3-(2-Arylhydrazono)-1,1,1-trifluro-3-(phenylsulfonyl)propan-2-ones as selective carboxylesterase inhibitors. Russ Chem Bull 2022, 71, 158-164. DOI:10.1007/s11172-022-3390-9
2021
- Bachurin, S. O.; Makhaeva, G. F.; Shevtsova, E. F.; Aksinenko, A. Y.; Grigoriev, V. V.; Shevtsov, P. N.; Goreva, T. V.; Epishina, T. A.; Kovaleva, N. V.; Pushkareva, E. A.; Boltneva, N. P.; Lushchekina, S. V.; Gabrelyan, A. V.; Zamoyski, V. L.; Dubova, L. G.; Rudakova, E. V.; Fisenko, V. P.; Bovina, E. V.; Richardson, R. J. Conjugation of Aminoadamantane and ?-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands. Molecules 2021, 26. DOI:10.3390/molecules26185527
- Melentev, P. A.; Ryabova, E. V.; Surina, N. V.; Zhmujdina, D. R.; Komissarov, A. E.; Ivanova, E. A.; Boltneva, N. P.; Makhaeva, G. F.; Sliusarenko, M. I.; Yatsenko, A. S.; Mohylyak, I. I.; Matiytsiv, N. P.; Shcherbata, H. R.; Sarantseva, S. V. Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain. Int J Mol Sci 2021, 22, 8275. DOI:10.3390/ijms22158275
- Makhaeva, G. F.; Serkov, I. V.; Kovaleva, N. V.; Rudakova, E. V.; Boltneva, N. P.; Kochetkova, E. A.; Proshin, A. N.; Bachurin, S. O. Novel conjugates of 4-Amino-2,3-polymethylenequinolines and vanillin as potential multitarget agents for AD treatment. Mendeleev Commun 2021, 31, 606–608. DOI:10.1016/j.mencom.2021.09.005
- Elkina, N. A.; Shchegolkov, E. V.; Burgart, Y. V.; Saloutin, V. I.; Boltneva, N. P.; Serebryakova, O. G.; Lushchekina, S. V.; Makhaeva, G. F. Synthesis of new efficient and selective carboxylesterase inhibitors based on adamantyl and citronellyl 4,4,4-trifluoro-2-arylhydrazonylidene-3-oxobutanoates. Russ Chem Bull 2021, 70, 567-572. DOI:10.1007/s11172-021-3126-2
- Makhaeva, G. F.; Lushchekina, S. V.; Boltneva, N. P.; Serebryakova, O. G.; Kovaleva, N. V.; Rudakova, E. V.; Elkina, N. A.; Shchegolkov, E. V.; Burgart, Y. V.; Stupina, T. S.; Terentiev, A. A.; Radchenko, E. V.; Palyulin, V. A.; Saloutin, V. I.; Bachurin, S. O.; Richardson, R. J. Novel Potent Bifunctional Carboxylesterase Inhibitors Based on a Polyfluoroalkyl-2-imino-1,3-dione Scaffold. Eur J Med Chem 2021, 217, 113385. DOI:10.1016/j.ejmech.2021.113385
- Makhaeva, G. F.; Lushchekina, S. V.; Kovaleva, N. V.; Yu Astakhova, T.; Boltneva, N. P.; Rudakova, E. V.; Serebryakova, O. G.; Proshin, A. N.; Serkov, I. V.; Trofimova, T. P.; Tafeenko, V. A.; Radchenko, E. V.; Palyulin, V. A.; Fisenko, V. P.; Korabecny, J.; Soukup, O.; Richardson, R. J. Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment. Bioorg Chem 2021, 112, 104974. DOI:10.1016/j.bioorg.2021.104974
2020
- Richardson, R. J.; Fink, J. K.; Glynn, P.; Hufnagel, R. B.; Makhaeva, G. F.; Wijeyesakere, S. J. Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN). Advances in Neurotoxicology 2020, 4, 1-78. DOI:10.1016/bs.ant.2020.01.001
- Richardson, R. J.; Fink, J. K.; Worden, R. M.; Wijeyesakere, S. J.; Makhaeva, G. F. Neuropathy target esterase as a biomarker and biosensor of delayed neuropathic agents. In Handbook of Toxicology of Chemical Warfare Agents, 3rd Ed.; R. Gupta Ed. Elsevier, San Diego: 2020; pp 1005-1025.
- Makhaeva, G. F.; Kovaleva, N. V.; Boltneva, N. P.; Lushchekina, S. V.; Rudakova, E. V.; Stupina, T. S.; Terentiev, A. A.; Serkov, I. V.; Proshin, A. N.; Radchenko, E. V.; Palyulin, V. A.; Bachurin, S. O.; Richardson, R. J. Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation. Bioorg Chem 2020, 94, 103387. DOI:10.1016/j.bioorg.2019.103387
- Makhaeva, G. F.; Shevtsova, E. F.; Aksinenko, A. Y.; Kovaleva, N. V.; Boltneva, N. P.; Lushchekina, S. V.; Rudakova, Е. V.; Pushkareva, E. A.; Serkova, T. P.; Dubova, L. G.; Shevtsov, P. N.; Sokolov, V. B.; Radchenko, E. V.; Palyulin, V. A.; Bachurin, S. O.; Richardson, R. J. Bis-gamma-carbolines as new potential multitarget agents for Alzheimer’s disease. Pure Appl Chem 2020, 92, 1057-1080. DOI:10.1515/pac-2019-1206
- Makhaeva, G. F.; Kovaleva, N. V.; Rudakova, E. V.; Boltneva, N. P.; Lushchekina, S. V.; Faingold, I. I.; Poletaeva, D. A.; Soldatova, Y. V.; Kotelnikova, R. A.; Serkov, I. V.; Ustinov, A. K.; Proshin, A. N.; Radchenko, E. V.; Palyulin, V. A.; Richardson, R. J. New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment. Molecules 2020, 25, 5891. DOI:http://dx.doi.org/10.3390/molecules25245891
- Makhaeva, G. F.; Kovaleva, N. V.; Boltneva, N. P.; Lushchekina, S. V.; Astakhova, T. Y.; Rudakova, E. V.; Proshin, A. N.; Serkov, I. V.; Radchenko, E. V.; Palyulin, V. A.; Bachurin, S. O.; Richardson, R. J. New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment. Molecules 2020, 25, 25173915. DOI:10.3390/molecules25173915
- Burgart, Y. V.; Agafonova, N. A.; Shchegolkov, E. V.; Krasnykh, O. P.; Kushch, S. O.; Evstigneeva, N. P.; Gerasimova, N. A.; Maslova, V. V.; Triandafilova, G. A.; Solodnikov, S. Y.; Ulitko, M. V.; Makhaeva, G. F.; Rudakova, E. V.; Borisevich, S. S.; Zilberberg, N. V.; Kungurov, N. V.; Saloutin, V. I.; Chupakhin, O. N. Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation. Eur J Med Chem 2020, 208, 112768. DOI:10.1016/j.ejmech.2020.112768
- Akimov, M. G.; Kudryavtsev, D. S.; Kryukova, E. V.; Fomina-Ageeva, E. V.; Zakharov, S. S.; Gretskaya, N. M.; Zinchenko, G. N.; Serkov, I. V.; Makhaeva, G. F.; Boltneva, N. P.; Kovaleva, N. V.; Serebryakova, O. G.; Lushchekina, S. V.; Palikov, V. A.; Palikova, Y.; Dyachenko, I. A.; Kasheverov, I. E.; Tsetlin, V. I.; Bezuglov, V. V. Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System. Biomolecules 2020, 10. DOI:10.3390/biom10020283
- Makhaeva, G. F.; Kovaleva, N. V.; Boltneva, N. P.; Lushchekina, S. V.; Rudakova, E. V.; Stupina, T. S.; Terentiev, A. A.; Serkov, I. V.; Proshin, A. N.; Radchenko, E. V.; Palyulin, V. A.; Bachurin, S. O.; Richardson, R. J. Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer’s disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation. Bioorg Chem 2020, 94, 103387 DOI:10.1016/j.bioorg.2019.103387
2019
- Makhaeva, G. F.; Shevtsova, E. F.; Boltneva, N. P.; Lushchekina, S. V.; Kovaleva, N. V.; Rudakova, E. V.; Bachurin, S. O.; Richardson, R. J. Overview of novel multifunctional agents based on conjugates of gamma-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease. Chem Biol Interact 2019, 308, 224-234. DOI:10.1016/j.cbi.2019.05.020
- Makhaeva, G. F.; Rudakova, E. V.; Kovaleva, N. V.; Lushchekina, S. V.; Boltneva, N. P.; Proshin, A. N.; Shchegolkov, E. V.; Burgart, Y. V.; Saloutin, V. I. Cholinesterase and carboxylesterase inhibitors as pharmacological agents. Russ Chem Bull 2019, 68, 967-984. DOI:10.1007/s11172-019-2507-2
- Makhaeva, G. F.; Elkina, N. A.; Shchegolkov, E. V.; Boltneva, N. P.; Lushchekina, S. V.; Serebryakova, O. G.; Rudakova, E. V.; Kovaleva, N. V.; Radchenko, E. V.; Palyulin, V. V.; Burgart, Y. V.; Saloutin, V. I.; Bachurin, S. O.; Richardson, R. J. Synthesis, molecular docking, and biological evaluation of 3–oxo–2–tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors. Bioorg Chem 2019, 91, 103097. DOI:10.1016/j.bioorg.2019.103097
- Khudina, O.; Makhaeva, G.; Elkina, N. A.; Boltneva, N.; Serebryakova, O.; Shchegolkov, E.; Rudakova, E.; Lushchekina, S.; Burgart, Y.; Bachurin, S.; Richardson, R.; Saloutin, V. Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers. Bioorg Med Chem Lett 2019, 29, 126716. DOI:10.1016/j.bmcl.2019.126716
- Bachurin, S. O.; Makhaeva, G. F.; Shevtsova, E. F.; Boltneva, N. P.; Kovaleva, N. V.; Lushchekina, S. V.; Rudakova, E. V.; Dubova, L. G.; Vinogradova, D. V.; Sokolov, V. B.; Aksinenko, A. Y.; Fisenko, V. P.; Richardson, R. J.; Aliev, G. Conjugates of methylene blue with gamma-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases. Sci Rep 2019, 9, 4873. DOI:10.1038/s41598-019-41272-4
2018
- Lushchekina, S. V.; Makhaeva, G. F.; Novichkova, D. A.; Zueva, I. V.; Kovaleva, N. V.; Richardson, R. J. Supercomputer modeling of dual-site acetylcholinesterase (AChE) inhibition. Supercomput Front Innov 2018, 5, 89-97. DOI:10.14529/jsfi1804
- Makhaeva, G. F.; Boltneva, N. P.; Lushchekina, S. V.; Rudakova, E. V.; Serebryakova, O. G.; Kulikova, L. N.; Beloglazkin, A. A.; Borisov, R. S.; Richardson, R. J. Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics. Bioorg Med Chem 2018, 26, 4716-4725. DOI:10.1016/j.bmc.2018.08.010
- Makhaeva, G. F.; Boltneva, N. P.; Kovaleva, N. V.; Rudakova, E. V.; Lushchekina, S. V.; Aksinenko, A. Y.; Sokolov, V. B. Influence of the gamma-carboline and carbazole pharmacophore moieties on anticholinesterase and antiradical activity of multifunctional agents for the treatment of neurodegenerative diseases. Russ Chem Bull 2018, 67, 1724-1731. DOI:10.1007/s11172-018-2282-5
- Boltneva, N. P.; Makhaeva, G. F.; Shchegol’kov, E. V.; Burgart, Y. V.; Saloutin, V. I. Selective Carboxylesterase Inhibitors for Improving Efficacy, Safety and Rational use of Ester-Containing Drugs. Biomed Chem: Res Methods 2018, 1, e00026. DOI:10.18097/bmcrm00026
- Makhaeva, G. F.; Rudakova, E. V.; Richardson, R. J. Investigation of the Esterase Status as a Complex Biomarker of Exposure to Organophosphorus Compounds. Biomed Chem: Res Methods 2018, 1, e00028. DOI:10.18097/bmcrm00028
- Nechaeva, N.; Prokopkina, T.; Makhaeva, G.; Rudakova, E.; Boltneva, N.; Dishovsky, C.; Eremenko, A.; Kurochkin, I. Quantitative butyrylcholinesterase activity detection by surface-enhanced Raman spectroscopy. Sensors and Actuators B: Chemical 2018, 259, 75-82. DOI:10.1016/j.snb.2017.11.174
2017
- Makhaeva, G. F.; Lushchekina, S. V.; Boltneva, N. P.; Serebryakova, O. G.; Rudakova, E. V.; Ustyugov, A. A.; Bachurin, S. O.; Shchepochkin, A. V.; Chupakhin, O. N.; Charushin, V. N.; Richardson, R. J. 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment. Bioorg Med Chem 2017, 25, 5981-5994. DOI:10.1016/j.bmc.2017.09.028
- Makhaeva, G. F.; Sokolov, V. B.; Shevtsova, E. F.; Kovaleva, N. V.; Lushchekina, S. V.; Boltneva, N. P.; Rudakova, E. V.; Aksinenko, A. Y.; Shevtsov, P. N.; Neganova, M. E.; Dubova, L. G.; Bachurin, S. O. Focused design of polypharmacophoric neuroprotective compounds: Conjugates of ?-carbolines with carbazole derivatives and tetrahydrocarbazole. Pure Appl Chem 2017, 89, 1167-1184. DOI:10.1515/pac-2017-0308
- Shchegol'kov, E. V.; Makhaeva, G. F.; Boltneva, N. P.; Lushchekina, S. V.; Serebryakova, O. G.; Rudakova, E. V.; Kovaleva, N. V.; Burgart, Y. V.; Saloutin, V. I.; Chupakhin, O. N.; Bachurin, S. O.; Richardson, R. J. Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors. Bioorg Med Chem 2017, 25, 3997-4007. DOI:10.1016/j.bmc.2017.05.045
- Bachurin, S. O.; Shevtsova, E. F.; Makhaeva, G. F.; Grigoriev, V. V.; Boltneva, N. P.; Kovaleva, N. V.; Lushchekina, S. V.; Shevtsov, P. N.; Neganova, M. E.; Redkozubova, O. M.; Bovina, E. V.; Gabrelyan, A. V.; Fisenko, V. P.; Sokolov, V. B.; Aksinenko, A. Y.; Echeverria, V.; Barreto, G. E.; Aliev, G. Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment. Sci Rep 2017, 7, 45627. DOI:10.1038/srep45627
2016
- Makhaeva, G. F.; Rudakova, E. V.; Serebryakova, O. G.; Aksinenko, A. Y.; Lushchekina, S. V.; Bachurin, S. O.; Richardson, R. J. Esterase profiles of organophosphorus compounds in vitro predict their behavior in vivo. Chem Biol Interact 2016, 259, 332-342. DOI:10.1016/j.cbi.2016.05.002
- Makhaeva, G. F.; Rudakova, E. V.; Sigolaeva, L. V.; Kurochkin, I. N.; Richardson, R. J. Neuropathy target esterase in mouse whole blood as a biomarker of exposure to neuropathic organophosphorus compounds. J Appl Toxicol 2016, 36, 1468-75. DOI:10.1002/jat.3305
- Makhaeva, G. F.; Boltneva, N. P.; Lushchekina, S. V.; Serebryakova, O. G.; Stupina, T. S.; Terentiev, A. A.; Serkov, I. V.; Proshin, A. N.; Bachurin, S. O.; Richardson, R. J. Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors. Bioorg Med Chem 2016, 24, 1050-1062. DOI:10.1016/j.bmc.2016.01.031
- Varfolomeev, S. D.; Lushchekina, S. V.; Nemukhin, A. V.; Kulakova, A. M.; Kots, E. D.; Makhaeva, G. F.; Delacour, H.; Lockridge, O.; Masson, P. Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins. Russ Chem Bull 2016, 65, 1592-1607. DOI:10.1007/s11172-016-1487-8
2015 и ранее
- Makhaeva, G. F.; Lushchekina, S. V.; Boltneva, N. P.; Sokolov, V. B.; Grigoriev, V. V.; Serebryakova, O. G.; Vikhareva, E. A.; Aksinenko, A. Y.; Barreto, G. E.; Aliev, G.; Bachurin, S. O. Conjugates of g-carbolines and phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer disease. Sci Rep 2015, 5, 13164. DOI:10.1038/srep13164
- Richardson, R. J.; Worden, R. M.; Wijeyesakere, S. J.; Hein, N. D.; Fink, J. K.; Makhaeva, G. F. Chapter 63 - Neuropathy Target Esterase as a Biomarker and Biosensor of Delayed Neuropathic Agents. In Handbook of Toxicology of Chemical Warfare Agents (Second Edition) , Gupta, R. C., Ed. Academic Press: Boston, 2015; pp 935-952.
- Makhaeva, G. F.; Rudakova, E. V.; Hein, N. D.; Serebryakova, O. G.; Kovaleva, N. V.; Boltneva, N. P.; Fink, J. K.; Richardson, R. J. Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds. J Appl Toxicol 2014, n/a-n/a. DOI:10.1002/jat.2977
- Makhaeva, G. F.; Radchenko, E. V.; Palyulin, V. A.; Rudakova, E. V.; Aksinenko, A. Y.; Sokolov, V. B.; Zefirov, N. S.; Richardson, R. J. Organophosphorus compound esterase profiles as predictors of therapeutic and toxic effects. Chem Biol Interact 2013, 203, 231-237. DOI:10.1016/j.cbi.2012.10.012
- Richardson, R. J.; Hein, N. D.; Wijeyesakere, S. J.; Fink, J. K.; Makhaeva, G. F. Neuropathy target esterase (NTE): overview and future. Chem Biol Interact 2013, 203, 238-44. DOI:10.1016/j.cbi.2012.10.024
- Rudakova, E. V.; Boltneva, N. P.; Makhaeva, G. F. Comparative analysis of esterase activities of human, mouse, and rat blood. Bull Exp Biol Med 2011, 152, 73-5. DOI:10.1007/s10517-011-1457-y
- Sigolaeva, L.; Makhaeva, G.; Rudakova, E.; Boltneva, N.; Porus, M.; Dubacheva, G.; Eremenko, A.; Kurochkin, I.; Richardson, R. J. Biosensor analysis of blood esterases for organophosphorus compounds exposure assessment: approaches to simultaneous determination of several esterases. Chem Biol Interact 2010, 187, 312-7. DOI:10.1016/j.cbi.2010.01.028
- Makhaeva, G. F.; Aksinenko, A. Y.; Sokolov, V. B.; Baskin, I. I.; Palyulin, V. A.; Zefirov, N. S.; Hein, N. D.; Kampf, J. W.; Wijeyesakere, S. J.; Richardson, R. J. Kinetics and mechanism of inhibition of serine esterases by fluorinated aminophosphonates. Chem Biol Interact 2010, 187, 177-184. DOI:10.1016/j.cbi.2009.12.018
- Makhaeva, G.; Rudakova, E.; Boltneva, N.; Sigolaeva, L.; Eremenko, A.; Kurochkin, I.; Richardson, R. Blood Esterases as a Complex Biomarker for Exposure to Organophosphorus Compounds. In Counteraction to Chemical and Biological Terrorism in East European Countries, Dishovsky, C.; Pivovarov, A., Eds. Springer Netherlands: 2009; pp 177-194.
- Kurochkin, I. N.; Eremenko, A. V.; Makhaeva, G. F.; Sigolaeva, L. V.; Dubacheva, G. G.; Richardson, R. J. Multi-Strip Assay and Multimodal Biosensors for Environmental and Medical Monitoring of Neurotoxicants. In Counteraction to Chemical and Biological Terrorism in East European Countries, Dishovsky, C.; Pivovarov, A., Eds. Springer Netherlands: 2009; pp 219-229.
- Makhaeva, G. F.; Malygin, V. V.; Strakhova, N. N.; Sigolaeva, L. V.; Sokolovskaya, L. G.; Eremenko, A. V.; Kurochkin, I. N.; Richardson, R. J. Biosensor assay of neuropathy target esterase in whole blood as a new approach to OPIDN risk assessment: review of progress. Hum Exp Toxicol 2007, 26, 273-82. DOI:10.1177/0960327106070463
- Sokolovskaya, L. G.; Sigolaeva, L. V.; Eremenko, A. V.; Gachok, I. V.; Makhaeva, G. F.; Strakhova, N. N.; Malygin, V. V.; Richardson, R. J.; Kurochkin, I. N. Improved electrochemical analysis of neuropathy target esterase activity by a tyrosinase carbon paste electrode modified by 1-methoxyphenazine methosulfate. Biotechnol Lett 2005, 27, 1211-8. DOI:10.1007/s10529-005-0020-1
- Malygin, V. V.; Sokolov, V. B.; Richardson, R. J.; Makhaeva, G. F. Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of O-alkyl-O-methylchloroformimino phenylphosphonates. J Toxicol Environ Health A 2003, 66, 611-25. DOI: 10.1080/15287390309353770
- Makhaeva, G. F.; Sigolaeva, L. V.; Zhuravleva, L. V.; Eremenko, A. V.; Kurochkin, I. N.; Malygin, V. V.; Richardson, R. J. Biosensor detection of neuropathy target esterase in whole blood as a biomarker of exposure to neuropathic organophosphorus compounds J Toxicol Environ Health A 2003, 66, 599-610. DOI:10.1080/15287390309353769
- Sigolaeva, L. V.; Makower, A.; Eremenko, A. V.; Makhaeva, G. F.; Malygin, V. V.; Kurochkin, I. N.; Scheller, F. W. Bioelectrochemical analysis of neuropathy target esterase activity in blood. Anal Biochem 2001, 290, 1-9. DOI:10.1006/abio.2000.4822
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